Isolation and Characterization of Neural Progenitor Cells From Bone Marrow in Cell Replacement Therapy of Brain Injury

Isolation and Characterization of Neural Progenitor Cells From Bone Marrow in Cell Replacement Therapy of Brain Injury

Blog Article

Many studies supported that bone marrow mesenchymal stem cells (BM-MSCs) can differentiate into neural cells, but few researchers detected mature and function of nerve cells, especially in vivo study.Some researchers even suggested that BM-MSCs transplantation would not be able to differentiate into functional neural cells.To figure out the dispute, this study examined bone marrow-derived sphere-like cells, harvested via neural stem cell suspension culture, then identified sukin body lotion woolworths as bone marrow-derived neural progenitor cells (BM-NPCs) by finding the expression of neural progenitor cells genes and proteins, neural progenitor cells characteristic and nerve cell differentiation induced through both methods.Moreover, BM-NPCs transplantation showed long-term survival and improved the ethological and histological indexes of brain injury rats, demonstrating ilootpaperie functional nervous cells differentiated from BM-NPCs.These in vitro and in vivo results confirmed BM-NPCs differentiating into mature and functional nerve cells.

This study provided valuable experimental data for BM-NPCs, suggesting a potential alternative treatment of central nervous injury disease.